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Question 1 of 21
An order is received to start dopamine at 5 mcg/kg/min in a patient weighing 88 kg.
What is the correct infusion rate in mL/hr? (Answer should be numeric; round to the nearest WHOLE number).
Question 2 of 21
Patient Case: Name: SGDiagnosis: Metastatic breast cancerChemotherapy Regimen: AC (Doxorubicin + Cyclophosphamide)Cycle Length: 21 days
Weight: 62; Height: 160
Chemotherapy Dosing Regimen:
Drug Dose Route Days of Cycle
Doxorubicin
60 mg/m²
IV
Day 1
Cyclophosphamide
600 mg/m²
IV
Day 1
Using the information provided, calculate the total dose of Cyclophosphamide (in mg) to be given on Day 1 of the cycle.
Question 3 of 21
A solution containing 1,000 mg of vancomycin in 20 mL of sterile water is added to 180 mL of 0.9% sodium chloride. The total infusion is to be administered over 90 minutes. The IV administration set delivers 20 drops/mL.
What is the infusion rate in drops per minute? (Answer should be numeric; Round your final answer to the nearest whole number.)
Question 4 of 21
Patient Profile:
Drug: Gentamicin
Elimination rate constant (ke): 0.15 hr⁻¹
Half-life (t½): 4.6 hours
Clearance (Cl): 5.25 L/hr
Calculate the volume of distribution (Vd) for gentamicin in this patient.Round your answer to the nearest WHOLE number.
Question 5 of 21
A randomized controlled trial was conducted to evaluate the effectiveness of Drug A in reducing cardiovascular events compared to placebo.
Group Event Rate
Drug A
8%
Placebo
12%
Relative Risk (RR)
0.67 (95% CI: 0.51 – 0.88)
What can be concluded from the relative risk and its confidence interval?
Question 6 of 21
An oral solution of mercaptopurine (Purixan) is prescribed at a dose of 75 mg/m²/day for maintenance therapy in acute lymphoblastic leukemia (ALL). The drug is available as an oral suspension: 20 mg/mL A 13-year-old patient weighs 50 kg and is 160 cm tall.
How many mL of suspension should be administered daily? Answer should be numeric; round to the nearest 0.5 mL.
Question 7 of 21
A nutrition bar contains 7 g of saturated fat per 50 g bar. The general recommendation for saturated fat intake is 20 g per day based on a 2,000-calorie diet. Calculate the % Daily Value (%DV) of saturated fat provided by one nutrition bar.Answer must be numeric; round the final answer to the nearest WHOLE NUMBER.
Question 8 of 21
High-Dose Heparin Protocol:
aPTT (sec)
Infusion Rate Adjustment
< 35
Bolus 60 U/kg, ↑ by 4 U/kg/hr
35–49
Bolus 40 U/kg, ↑ by 3 U/kg/hr
50–69
↑ by 2 U/kg/hr
70–99
No change
100–120
↓ by 1 U/kg/hr
>120
Hold 1 hr, ↓ by 2 U/kg/h
Patient weight: 72 kgCurrent rate: 18 units/kg/hr
A patient is receiving heparin therapy using the high-dose heparin protocol. Six hours after starting the infusion, the patient’s aPTT is found to be 110 seconds.
Based on the high-dose protocol above, what should the new infusion rate (in units/hr) adjustment be? (Answer should be numeric; round to the nearest whoe number)
Question 9 of 21
Rx:
Calculate the concentration of Ca²⁺ in mEq/L in the final preparation. (Round final answer to TWO decimal places)
Question 10 of 21
A hospital pharmacy receives an order to prepare 120 mL of a 2.5% lidocaine hydrochloride solution. The only available stock solution is 10% lidocaine hydrochloride.
What volume (in mL) of the 10% stock solution is needed? Round your final answer to the nearest WHOLE NUMBER.
Question 11 of 21
A 100 mg IV dose of Drug A (F = 1) achieves an area under the curve (AUC) of 40 mcg·hr/mL. The oral tablet formulation has a bioavailability (F) of 0.5.
What oral dose (in mg) is required to achieve the same AUC of 40 mcg·hr/mL? Round your final answer to the nearest WHOLE NUMBER.
Question 12 of 21
67-year-old male patient weighs 60 kg and is 5’8” tall. His serum creatinine is 1.6 mg/dL. The pharmacy is reviewing orders for aminoglycoside therapy, which requires renal adjustment based on creatinine clearance (CrCl). Use the Cockcroft-Gault equation to calculate the patient’s CrCl. Refer to the dosing protocol below to determine if the dosing interval for aminoglycoside needs to be adjusted
Answer must be numeric; round the final CrCl to the nearest WHOLE NUMBER.
CrCl (mL/min)
Recommended Dosing Interval
> 60
Every 8 hours
40 – 60
Every 12 hours
20 – 39
Every 24 hours
< 20
Based on levels
Question 13 of 21
A 62-year-old male patient is receiving the following total parenteral nutrition (TPN) order:
Component
Amount Ordered
Stock Concentration
Dextrose
300 g/day
70% Dextrose (i.e., 0.7 g/mL)
Amino acids (Protein)
85 g/day
15% Amino Acid
Lipid emulsion
500 mL/day
20% Lipid Emulsion (2 kcal/mL)
Total TPN volume
2000 mL/day
What percentage of total daily calories is provided by dextrose in this TPN?(Answer must be numeric; round the final answer to the nearest whole number.)
Question 14 of 21
A pharmacy technician is preparing an ophthalmic solution. The prescription reads:
Rx:
Tetracaine hydrochloride 0.5% w/v
Make isotonic solution
E-value of tetracaine HCl = 0.20
E-value of benzalkonium chloride = 0.16
Sodium chloride equivalent = 0.9% for isotonicity
How many grams of sodium chloride should be added to make the solution isotonic? (Round final answer to the nearest TENTH.)
Question 15 of 21
A compounding pharmacist must prepare 60 g of a 3% salicylic acid ointment using available 2% and 6% salicylic acid ointments.
How many grams of the 6% ointment should be used? (Round final answer to the nearest whole number)
Question 16 of 21
Clinical Trial Background:
A randomized controlled trial was conducted to assess the effectiveness of Drug Y in preventing stroke in high-risk patients with atrial fibrillation. Patients were randomly assigned to receive either Drug Y or placebo for a follow-up period of 3 years.
Table of Clinical Trial Results:
Endpoint Drug Y Placebo Relative Risk (RR) P-value
Stroke incidence
4.5%
7.5%
0.60 (0.50 – 0.72)
< 0.001
Based on the data above, what is the Number Needed to Treat (NNT) to prevent one stroke with Drug Y compared to placebo?
Question 17 of 21
Name: SLAge: 58 yearsWeight: 70 kgClinical Status: NPO following bowel resection; receiving full parenteral nutrition
TPN Formula (24-hour infusion)
Component Amount Ordered Stock Concentration
Dextrose
300 g/day
70% Dextrose
Amino Acids (Protein)
85 g/day
10% Amino Acids
IV Lipids
500 mL/day
20% Lipid Emulsion
Sodium Acetate
50 mEq/day
2 mEq/mL
Potassium Chloride
60 mEq/day
2 mEq/mL
Magnesium Sulfate
16 mEq/day
4 mEq/mL
Sodium Phosphate
20 mmol/day
3 mmol/mL
Calcium Gluconate
10 mEq/day
0.465 mEq/mL
Multivitamins
10 mL/day
Adult MVI
Trace Elements
5 mL/day
Tralement
Total Volume
2000 mL/day
–
What percentage of total daily calories in this TPN is provided by dextrose? (Answer must be numeric; round to the nearest WHOLE NUMBER.)
Question 18 of 21
Patient Profile:
What is the half-life of theophylline in this patient? Answer must be numeric; round to the nearest TENTH.
Question 19 of 21
An 80 kg patient is transitioning from IV Bactrim therapy at a dosage of 15 mg/kg (based on the trimethoprim component) twice daily to oral therapy to complete an additional 8-day course of treatment.
How many Bactrim DS tablets should be prescribed to match the IV therapy dosage for the full duration? (Answer must be numeric; round to the nearest WHOLE NUMBER.)
Question 20 of 21
A compounding pharmacist is preparing a topical antifungal cream. The prescription requires adding 5 grams of ketoconazole to 100 grams of a cream base that already contains 2% ketoconazole.(Answer must be numeric; round the final answer to the nearest TENTH.)
Question 21 of 21
How much NaCl is needed to make 100 mL isotonic solution with Pilocarpine nitrate 1% ?
